Oxidation of DNA bases is influenced by their position in the DNA strand
Electrochemical detection of DNA is an important field of research, with strong implications for next generation diagnostics. In this paper, we show that the electrochemical responses of DNA bases (guanine, adenine, thymine, cytosine) in terms of peak potentials and peak current may be influenced by...
Saved in:
Main Authors: | , , |
---|---|
Other Authors: | |
Format: | Article |
Language: | English |
Published: |
2013
|
Online Access: | https://hdl.handle.net/10356/96083 http://hdl.handle.net/10220/10848 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Nanyang Technological University |
Language: | English |
id |
sg-ntu-dr.10356-96083 |
---|---|
record_format |
dspace |
spelling |
sg-ntu-dr.10356-960832020-03-07T12:31:30Z Oxidation of DNA bases is influenced by their position in the DNA strand Toh, Rou Jun Bonanni, Alessandra Pumera, Martin School of Physical and Mathematical Sciences Electrochemical detection of DNA is an important field of research, with strong implications for next generation diagnostics. In this paper, we show that the electrochemical responses of DNA bases (guanine, adenine, thymine, cytosine) in terms of peak potentials and peak current may be influenced by the sequences of an oligomer at standard glassy carbon (GC), as well as electrochemically reduced graphene oxide electrode. We have observed that the effects were more significant on the oxidative peaks of adenine and thymine on the GC-electrode. Deviations in peak potentials were generally low. Our findings are principally important for fundamental studies and future developments in DNA detection and analysis. 2013-07-01T04:50:13Z 2019-12-06T19:25:20Z 2013-07-01T04:50:13Z 2019-12-06T19:25:20Z 2012 2012 Journal Article Toh, R. J., Bonanni, A., & Pumera, M. (2012). Oxidation of DNA bases is influenced by their position in the DNA strand. Electrochemistry Communications, 22, 207-210. 1388-2481 https://hdl.handle.net/10356/96083 http://hdl.handle.net/10220/10848 10.1016/j.elecom.2012.06.025 en Electrochemistry communications © 2012 Elsevier B.V. |
institution |
Nanyang Technological University |
building |
NTU Library |
country |
Singapore |
collection |
DR-NTU |
language |
English |
description |
Electrochemical detection of DNA is an important field of research, with strong implications for next generation diagnostics. In this paper, we show that the electrochemical responses of DNA bases (guanine, adenine, thymine, cytosine) in terms of peak potentials and peak current may be influenced by the sequences of an oligomer at standard glassy carbon (GC), as well as electrochemically reduced graphene oxide electrode. We have observed that the effects were more significant on the oxidative peaks of adenine and thymine on the GC-electrode. Deviations in peak potentials were generally low. Our findings are principally important for fundamental studies and future developments in DNA detection and analysis. |
author2 |
School of Physical and Mathematical Sciences |
author_facet |
School of Physical and Mathematical Sciences Toh, Rou Jun Bonanni, Alessandra Pumera, Martin |
format |
Article |
author |
Toh, Rou Jun Bonanni, Alessandra Pumera, Martin |
spellingShingle |
Toh, Rou Jun Bonanni, Alessandra Pumera, Martin Oxidation of DNA bases is influenced by their position in the DNA strand |
author_sort |
Toh, Rou Jun |
title |
Oxidation of DNA bases is influenced by their position in the DNA strand |
title_short |
Oxidation of DNA bases is influenced by their position in the DNA strand |
title_full |
Oxidation of DNA bases is influenced by their position in the DNA strand |
title_fullStr |
Oxidation of DNA bases is influenced by their position in the DNA strand |
title_full_unstemmed |
Oxidation of DNA bases is influenced by their position in the DNA strand |
title_sort |
oxidation of dna bases is influenced by their position in the dna strand |
publishDate |
2013 |
url |
https://hdl.handle.net/10356/96083 http://hdl.handle.net/10220/10848 |
_version_ |
1681039653281464320 |