Substrate channel flexibility in Pseudomonas aeruginosa MurB accommodates two distinct substrates

• Main Authors: Chen, Ming Wei, Lohkamp, Bernhard, Schnell, Robert, Lescar, Julien, Schneider, Gunter
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/96311; http://hdl.handle.net/10220/11918
• Institution: Nanyang Technological University

Biosynthesis of UDP-N-acetylmuramic acid in bacteria is a committed step towards peptidoglycan production. In an NADPH- and FAD-dependent reaction, the UDP-N-acetylglucosamine-enolpyruvate reductase (MurB) reduces UDP-N-acetylglucosamine-enolpyruvate to UDP-N-acetylmuramic acid. We determined the th...