Structural basis of the PNRC2-mediated Link between mRNA surveillance and decapping

• Main Authors: Liu, Zhou, Piao, Shunfu, Parker, Roy, Lai, Tingfeng, Cho, Hana, Kim, Yoon Ki, Song, Haiwei, Bowler, Matthew W.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/96349; http://hdl.handle.net/10220/11938
• Institution: Nanyang Technological University

Nonsense-mediated mRNA decay (NMD) is an important mRNA surveillance system, and human PNRC2 protein mediates the link between mRNA surveillance and decapping. However, the mechanism by which PNRC2 interacts with the mRNA surveillance machinery and stimulates NMD is unknown. Here, we present the cry...