Zebrafish hoxd4a acts upstream of meis1.1 to direct vasculogenesis, angiogenesis and hematopoiesis

• Main Authors: Amali, Aseervatham Anusha, Sie, Lawrence, Winkler, Christoph, Featherstone, Mark
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences::Zoology::Morphology
• Online Access: https://hdl.handle.net/10356/96401; http://hdl.handle.net/10220/9879
• Institution: Nanyang Technological University

Mice lacking the 4th-group paralog Hoxd4 display malformations of the anterior vertebral column, but are viable and fertile. Here, we report that zebrafish embryos having decreased function of the orthologous hoxd4a gene manifest striking perturbations in vasculogenesis, angiogenesis and primitive...