A role of Kindlin-3 in integrin αMβ2 outside-in signaling and the Syk-Vav1-Rac1/Cdc42 signaling axis

• Main Authors: Xue, Zhi-Hong, Feng, Chen, Liu, Weiling, Tan, Suet Mien
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences::Genetics
• Online Access: https://hdl.handle.net/10356/96536; http://hdl.handle.net/10220/9890
• Institution: Nanyang Technological University

Integrins mediate cell-cell and cell-extracellular matrix attachments. Integrins are signaling receptors because their cytoplasmic tails are docking sites for cytoskeletal and signaling proteins. Kindlins are a family of band 4.1-ezrin-radixinmoesin- containing intracellular proteins. Apart from r...