Gene expression and pathway analysis of quiescent CD8+ T cells from liver cancer, liver sinusoid and peripheral blood : study on toxicogenomics and prevention targeting

The quiescent status of T cell immunology is associated with the development of tumor in liver cancer. However, the cause of T cell quiescence in the tumor microenvironment is still unclear. Recently, it has been proposed that toxic substances could inhibit T-cell immune response to tumor cells. Sin...

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Main Authors: Wang, Zhaohui, Hu, Hongliang, Zheng, Jie, Li, Biaoru
Other Authors: School of Computer Engineering
Format: Conference or Workshop Item
Language:English
Published: 2013
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Online Access:https://hdl.handle.net/10356/96548
http://hdl.handle.net/10220/17351
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Institution: Nanyang Technological University
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spelling sg-ntu-dr.10356-965482020-05-28T07:17:47Z Gene expression and pathway analysis of quiescent CD8+ T cells from liver cancer, liver sinusoid and peripheral blood : study on toxicogenomics and prevention targeting Wang, Zhaohui Hu, Hongliang Zheng, Jie Li, Biaoru School of Computer Engineering IEEE International Conference on Bioinformatics and Bioengineering (11th : 2011 : Taichung, Taiwan) DRNTU::Engineering::Bioengineering The quiescent status of T cell immunology is associated with the development of tumor in liver cancer. However, the cause of T cell quiescence in the tumor microenvironment is still unclear. Recently, it has been proposed that toxic substances could inhibit T-cell immune response to tumor cells. Since sinusoidal structure is primarily involved in anti-toxic function and toxic retaining mechanism, in this paper we study the role of liver sinusoid in liver tumor by comparing gene expression levels of quiescent genes in CD8+ T cells isolated from three sources: peripheral blood, sinusoidal structure, and tumor tissue. We observed that most quiescent genes are up regulated in CD8+ T cells isolated from sinusoidal structure as compared with those from liver tumor and peripheral blood. The genes and pathways predicted in this project will be candidates for drug targeting. Accepted version 2013-11-06T07:43:26Z 2019-12-06T19:32:21Z 2013-11-06T07:43:26Z 2019-12-06T19:32:21Z 2011 2011 Conference Paper Wang, Z., Hu, H., Zheng, J., & Li, B. (2011). Gene expression and pathway analysis of quiescent CD8+ T cells from liver cancer, liver sinusoid and peripheral blood - study on toxicogenomics and prevention targeting. 2011 IEEE 11th International Conference on Bioinformatics and Bioengineering, pp72-77. https://hdl.handle.net/10356/96548 http://hdl.handle.net/10220/17351 10.1109/BIBE.2011.18 en © 2011 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. The published version is available at: [http://dx.doi.org/10.1109/BIBE.2011.18] application/pdf
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
topic DRNTU::Engineering::Bioengineering
spellingShingle DRNTU::Engineering::Bioengineering
Wang, Zhaohui
Hu, Hongliang
Zheng, Jie
Li, Biaoru
Gene expression and pathway analysis of quiescent CD8+ T cells from liver cancer, liver sinusoid and peripheral blood : study on toxicogenomics and prevention targeting
description The quiescent status of T cell immunology is associated with the development of tumor in liver cancer. However, the cause of T cell quiescence in the tumor microenvironment is still unclear. Recently, it has been proposed that toxic substances could inhibit T-cell immune response to tumor cells. Since sinusoidal structure is primarily involved in anti-toxic function and toxic retaining mechanism, in this paper we study the role of liver sinusoid in liver tumor by comparing gene expression levels of quiescent genes in CD8+ T cells isolated from three sources: peripheral blood, sinusoidal structure, and tumor tissue. We observed that most quiescent genes are up regulated in CD8+ T cells isolated from sinusoidal structure as compared with those from liver tumor and peripheral blood. The genes and pathways predicted in this project will be candidates for drug targeting.
author2 School of Computer Engineering
author_facet School of Computer Engineering
Wang, Zhaohui
Hu, Hongliang
Zheng, Jie
Li, Biaoru
format Conference or Workshop Item
author Wang, Zhaohui
Hu, Hongliang
Zheng, Jie
Li, Biaoru
author_sort Wang, Zhaohui
title Gene expression and pathway analysis of quiescent CD8+ T cells from liver cancer, liver sinusoid and peripheral blood : study on toxicogenomics and prevention targeting
title_short Gene expression and pathway analysis of quiescent CD8+ T cells from liver cancer, liver sinusoid and peripheral blood : study on toxicogenomics and prevention targeting
title_full Gene expression and pathway analysis of quiescent CD8+ T cells from liver cancer, liver sinusoid and peripheral blood : study on toxicogenomics and prevention targeting
title_fullStr Gene expression and pathway analysis of quiescent CD8+ T cells from liver cancer, liver sinusoid and peripheral blood : study on toxicogenomics and prevention targeting
title_full_unstemmed Gene expression and pathway analysis of quiescent CD8+ T cells from liver cancer, liver sinusoid and peripheral blood : study on toxicogenomics and prevention targeting
title_sort gene expression and pathway analysis of quiescent cd8+ t cells from liver cancer, liver sinusoid and peripheral blood : study on toxicogenomics and prevention targeting
publishDate 2013
url https://hdl.handle.net/10356/96548
http://hdl.handle.net/10220/17351
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