Inherently electroactive graphene oxide nanoplatelets as labels for single nucleotide polymorphism detection

Graphene materials are being widely used in electrochemistry due to their versatility and excellent properties as platforms for biosensing. However, no records show the use of inherent redox properties of graphene oxide as a label for detection. Here for the first time we used graphene oxide nanopla...

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Main Authors: Bonanni, Alessandra, Chua, Chun Kiang, Zhao, Guanjia, Sofer, Zdeněk, Pumera, Martin
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2013
Online Access:https://hdl.handle.net/10356/96619
http://hdl.handle.net/10220/10300
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-966192020-03-07T12:34:43Z Inherently electroactive graphene oxide nanoplatelets as labels for single nucleotide polymorphism detection Bonanni, Alessandra Chua, Chun Kiang Zhao, Guanjia Sofer, Zdeněk Pumera, Martin School of Physical and Mathematical Sciences Graphene materials are being widely used in electrochemistry due to their versatility and excellent properties as platforms for biosensing. However, no records show the use of inherent redox properties of graphene oxide as a label for detection. Here for the first time we used graphene oxide nanoplatelets (GONPs) as electroactive labels for DNA analysis. The working signal comes from the reduction of the oxygen-containing groups present on the surface of GONPs. The different ability of the graphene oxide nanoplatelets to conjugate to DNA hybrids obtained with complementary, noncomplementary, and one-mismatch sequences allows the discrimination of single-nucleotide polymorphism correlated with Alzheimer’s disease. We believe that our findings are very important to open a new route in the use of graphene oxide in electrochemistry. 2013-06-13T02:53:09Z 2019-12-06T19:33:04Z 2013-06-13T02:53:09Z 2019-12-06T19:33:04Z 2012 2012 Journal Article Bonanni, A., Chua, C. K., Zhao, G., Sofer, Z., & Pumera, M. (2012). Inherently Electroactive Graphene Oxide Nanoplatelets As Labels for Single Nucleotide Polymorphism Detection. ACS Nano, 6(10), 8546-8551. 1936-0851 https://hdl.handle.net/10356/96619 http://hdl.handle.net/10220/10300 10.1021/nn301359y en ACS nano © 2012 American Chemical Society.
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
description Graphene materials are being widely used in electrochemistry due to their versatility and excellent properties as platforms for biosensing. However, no records show the use of inherent redox properties of graphene oxide as a label for detection. Here for the first time we used graphene oxide nanoplatelets (GONPs) as electroactive labels for DNA analysis. The working signal comes from the reduction of the oxygen-containing groups present on the surface of GONPs. The different ability of the graphene oxide nanoplatelets to conjugate to DNA hybrids obtained with complementary, noncomplementary, and one-mismatch sequences allows the discrimination of single-nucleotide polymorphism correlated with Alzheimer’s disease. We believe that our findings are very important to open a new route in the use of graphene oxide in electrochemistry.
author2 School of Physical and Mathematical Sciences
author_facet School of Physical and Mathematical Sciences
Bonanni, Alessandra
Chua, Chun Kiang
Zhao, Guanjia
Sofer, Zdeněk
Pumera, Martin
format Article
author Bonanni, Alessandra
Chua, Chun Kiang
Zhao, Guanjia
Sofer, Zdeněk
Pumera, Martin
spellingShingle Bonanni, Alessandra
Chua, Chun Kiang
Zhao, Guanjia
Sofer, Zdeněk
Pumera, Martin
Inherently electroactive graphene oxide nanoplatelets as labels for single nucleotide polymorphism detection
author_sort Bonanni, Alessandra
title Inherently electroactive graphene oxide nanoplatelets as labels for single nucleotide polymorphism detection
title_short Inherently electroactive graphene oxide nanoplatelets as labels for single nucleotide polymorphism detection
title_full Inherently electroactive graphene oxide nanoplatelets as labels for single nucleotide polymorphism detection
title_fullStr Inherently electroactive graphene oxide nanoplatelets as labels for single nucleotide polymorphism detection
title_full_unstemmed Inherently electroactive graphene oxide nanoplatelets as labels for single nucleotide polymorphism detection
title_sort inherently electroactive graphene oxide nanoplatelets as labels for single nucleotide polymorphism detection
publishDate 2013
url https://hdl.handle.net/10356/96619
http://hdl.handle.net/10220/10300
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