Inherently electroactive graphene oxide nanoplatelets as labels for single nucleotide polymorphism detection
Graphene materials are being widely used in electrochemistry due to their versatility and excellent properties as platforms for biosensing. However, no records show the use of inherent redox properties of graphene oxide as a label for detection. Here for the first time we used graphene oxide nanopla...
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sg-ntu-dr.10356-966192020-03-07T12:34:43Z Inherently electroactive graphene oxide nanoplatelets as labels for single nucleotide polymorphism detection Bonanni, Alessandra Chua, Chun Kiang Zhao, Guanjia Sofer, Zdeněk Pumera, Martin School of Physical and Mathematical Sciences Graphene materials are being widely used in electrochemistry due to their versatility and excellent properties as platforms for biosensing. However, no records show the use of inherent redox properties of graphene oxide as a label for detection. Here for the first time we used graphene oxide nanoplatelets (GONPs) as electroactive labels for DNA analysis. The working signal comes from the reduction of the oxygen-containing groups present on the surface of GONPs. The different ability of the graphene oxide nanoplatelets to conjugate to DNA hybrids obtained with complementary, noncomplementary, and one-mismatch sequences allows the discrimination of single-nucleotide polymorphism correlated with Alzheimer’s disease. We believe that our findings are very important to open a new route in the use of graphene oxide in electrochemistry. 2013-06-13T02:53:09Z 2019-12-06T19:33:04Z 2013-06-13T02:53:09Z 2019-12-06T19:33:04Z 2012 2012 Journal Article Bonanni, A., Chua, C. K., Zhao, G., Sofer, Z., & Pumera, M. (2012). Inherently Electroactive Graphene Oxide Nanoplatelets As Labels for Single Nucleotide Polymorphism Detection. ACS Nano, 6(10), 8546-8551. 1936-0851 https://hdl.handle.net/10356/96619 http://hdl.handle.net/10220/10300 10.1021/nn301359y en ACS nano © 2012 American Chemical Society. |
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Graphene materials are being widely used in electrochemistry due to their versatility and excellent properties as platforms for biosensing. However, no records show the use of inherent redox properties of graphene oxide as a label for detection. Here for the first time we used graphene oxide nanoplatelets (GONPs) as electroactive labels for DNA analysis. The working signal comes from the reduction of the oxygen-containing groups present on the surface of GONPs. The different ability of the graphene oxide nanoplatelets to conjugate to DNA hybrids obtained with complementary, noncomplementary, and one-mismatch sequences allows the discrimination of single-nucleotide polymorphism correlated with Alzheimer’s disease. We believe that our findings are very important to open a new route in the use of graphene oxide in electrochemistry. |
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School of Physical and Mathematical Sciences |
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School of Physical and Mathematical Sciences Bonanni, Alessandra Chua, Chun Kiang Zhao, Guanjia Sofer, Zdeněk Pumera, Martin |
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Bonanni, Alessandra Chua, Chun Kiang Zhao, Guanjia Sofer, Zdeněk Pumera, Martin |
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Bonanni, Alessandra Chua, Chun Kiang Zhao, Guanjia Sofer, Zdeněk Pumera, Martin Inherently electroactive graphene oxide nanoplatelets as labels for single nucleotide polymorphism detection |
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Bonanni, Alessandra |
title |
Inherently electroactive graphene oxide nanoplatelets as labels for single nucleotide polymorphism detection |
title_short |
Inherently electroactive graphene oxide nanoplatelets as labels for single nucleotide polymorphism detection |
title_full |
Inherently electroactive graphene oxide nanoplatelets as labels for single nucleotide polymorphism detection |
title_fullStr |
Inherently electroactive graphene oxide nanoplatelets as labels for single nucleotide polymorphism detection |
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Inherently electroactive graphene oxide nanoplatelets as labels for single nucleotide polymorphism detection |
title_sort |
inherently electroactive graphene oxide nanoplatelets as labels for single nucleotide polymorphism detection |
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2013 |
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https://hdl.handle.net/10356/96619 http://hdl.handle.net/10220/10300 |
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