Combinatorial effect of different alginate compositions, polycations, and gelling ions on microcapsule properties
Microencapsulation technology is commonly used to deliver cells and drugs for therapeutic applications. The encapsulation material has a direct influence over the properties of microcapsules and will eventually dictate the efficacy of this delivery system. In this study, the combinatory effect o...
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| Main Authors: | , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
2013
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| Online Access: | https://hdl.handle.net/10356/96691 http://hdl.handle.net/10220/13091 |
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| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | Microencapsulation technology is commonly used
to deliver cells and drugs for therapeutic applications. The
encapsulation material has a direct influence over the properties
of microcapsules and will eventually dictate the efficacy
of this delivery system. In this study, the combinatory effect of
different alginate compositions, polycations and gelling ions
was investigated to determine their roles in affecting the
properties of the microcapsules. A multifactorial relationship
was found between the three factors, in which certain factors
took priority over others in influencing the overall property of
the microcapsules. As the size of the microcapsules was kept
constant throughout the investigation, further insights into the
role of fabrication parameters on microcapsules size were also
obtained. From the results, poly-L-lysine-coated microcapsules
fabricated from 40/60 sodium alginate and cross-linked
with barium chloride were the most ideal for applications that
require both good mechanical as well as diffusion properties. |
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