Insulin receptor substrate protein 53kDa (IRSp53) is a negative regulator of myogenic differentiation

• Main Authors: Misra, Ashish, George, Bhawana, Rajmohan, Rajamuthiah, Jain, Neeraj, Wong, Ming Hwa, Kambadur, Ravi, Thanabalu, Thirumaran
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/96780; http://hdl.handle.net/10220/11588
• Institution: Nanyang Technological University

Fusion of mononucleated myoblasts to generate multinucleated myotubes is a critical step in skeletal muscle development. Filopodia, the actin cytoskeleton based membrane protrusions, have been observed early during myoblast fusion, indicating that they could play a direct role in myogenic differenti...