Estimation of optimal insertion angle in a mammalian outer hair cell stereocilium
Optimal insertion angle of mammalian stereocilia is estimated from the finite element analysis of the tip motion of outer hair cells (OHCs) stereocilia. The OHC stereocilia motion in the acousticolateral system appears to result in the mechanoelectrical transduction channels. Deflection of the hair...
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sg-ntu-dr.10356-968552020-03-07T13:19:28Z Estimation of optimal insertion angle in a mammalian outer hair cell stereocilium Abedinnasab, Mohammad H. Baek, Jong Dae Yoon, Yong-Jin Han, Beibei Kwak, Sang Kyu School of Mechanical and Aerospace Engineering School of Chemical and Biomedical Engineering DRNTU::Engineering::Chemical engineering Optimal insertion angle of mammalian stereocilia is estimated from the finite element analysis of the tip motion of outer hair cells (OHCs) stereocilia. The OHC stereocilia motion in the acousticolateral system appears to result in the mechanoelectrical transduction channels. Deflection of the hair bundle towards the tallest row of stereocilia causes increased probability of opening of ion channels. In this work, we focus on one of the physical features of the OHC stereocilium, the initial insertion angle of the tallest row into the tectorial membrane (TM), and its effects on the stereocilia's deflection motion. A three-dimensional model was built for the tallest stereocilium and the TM at the region where the best frequency was 500Hz. The mechanical interactions between the embedded stereocilia and the TM have been implemented into the finite element simulation. We found that, the optimum insertion angle of the tallest stereocilium into the TM was 69.8°, where the stereocilium is maximally deflected. This quantity is consistent with the histological observation obtained from the literature. 2013-07-17T02:51:23Z 2019-12-06T19:35:46Z 2013-07-17T02:51:23Z 2019-12-06T19:35:46Z 2012 2012 Journal Article Baek, J. D., Yoon, Y.-J., Abedinnasab, M. H., Han, B., & Kwak, S. K. (2012). Estimation of optimal insertion angle in a mammalian outer hair cell stereocilium. Journal of Biomechanics, 45(10), 1823-1827. 0021-9290 https://hdl.handle.net/10356/96855 http://hdl.handle.net/10220/11654 10.1016/j.jbiomech.2012.04.012 en Journal of biomechanics © 2012 Elsevier. |
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DRNTU::Engineering::Chemical engineering Abedinnasab, Mohammad H. Baek, Jong Dae Yoon, Yong-Jin Han, Beibei Kwak, Sang Kyu Estimation of optimal insertion angle in a mammalian outer hair cell stereocilium |
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Optimal insertion angle of mammalian stereocilia is estimated from the finite element analysis of the tip motion of outer hair cells (OHCs) stereocilia. The OHC stereocilia motion in the acousticolateral system appears to result in the mechanoelectrical transduction channels. Deflection of the hair bundle towards the tallest row of stereocilia causes increased probability of opening of ion channels. In this work, we focus on one of the physical features of the OHC stereocilium, the initial insertion angle of the tallest row into the tectorial membrane (TM), and its effects on the stereocilia's deflection motion. A three-dimensional model was built for the tallest stereocilium and the TM at the region where the best frequency was 500Hz. The mechanical interactions between the embedded stereocilia and the TM have been implemented into the finite element simulation. We found that, the optimum insertion angle of the tallest stereocilium into the TM was 69.8°, where the stereocilium is maximally deflected. This quantity is consistent with the histological observation obtained from the literature. |
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School of Mechanical and Aerospace Engineering |
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School of Mechanical and Aerospace Engineering Abedinnasab, Mohammad H. Baek, Jong Dae Yoon, Yong-Jin Han, Beibei Kwak, Sang Kyu |
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Article |
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Abedinnasab, Mohammad H. Baek, Jong Dae Yoon, Yong-Jin Han, Beibei Kwak, Sang Kyu |
author_sort |
Abedinnasab, Mohammad H. |
title |
Estimation of optimal insertion angle in a mammalian outer hair cell stereocilium |
title_short |
Estimation of optimal insertion angle in a mammalian outer hair cell stereocilium |
title_full |
Estimation of optimal insertion angle in a mammalian outer hair cell stereocilium |
title_fullStr |
Estimation of optimal insertion angle in a mammalian outer hair cell stereocilium |
title_full_unstemmed |
Estimation of optimal insertion angle in a mammalian outer hair cell stereocilium |
title_sort |
estimation of optimal insertion angle in a mammalian outer hair cell stereocilium |
publishDate |
2013 |
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https://hdl.handle.net/10356/96855 http://hdl.handle.net/10220/11654 |
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1681046003015221248 |