Addition of glycosylation to influenza A virus hemagglutinin modulates antibody-mediated recognition of H1N1 2009 pandemic viruses

• Main Authors: Job, Emma R., Deng, Yi-Mo, Barfod, Kenneth K., Tate, Michelle D., Caldwell, Natalie, Reddiex, Scott, Maurer-Stroh, Sebastian, Brooks, Andrew G., Reading, Patrick C.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences::Microbiology::Immunology
• Online Access: https://hdl.handle.net/10356/96902; http://hdl.handle.net/10220/18079
• Institution: Nanyang Technological University

Seasonal influenza A viruses (IAV) originate from pandemic IAV and have undergone changes in antigenic structure, including addition of glycans to the viral hemagglutinin (HA). Glycans on the head of HA promote virus survival by shielding antigenic sites, but highly glycosylated seasonal IAV are ina...