Chemically bonded cationic β-cyclodextrin derivatives and their applications in supercritical fluid chromatography
Cationic β-cyclodextrin (CD) perphenylcarbamoylated derivatives were chemically bonded onto vinylized silica using a radical co-polymerization reaction. The derived materials were used as chiral stationary phases (CSP) in supercritical fluid chromatography (SFC). Enantioseparations were successfully...
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sg-ntu-dr.10356-969282020-03-07T11:35:34Z Chemically bonded cationic β-cyclodextrin derivatives and their applications in supercritical fluid chromatography Wang, Ren-Qi Ong, Teng-Teng Ng, Siu-Choon School of Chemical and Biomedical Engineering DRNTU::Engineering::Chemical engineering Cationic β-cyclodextrin (CD) perphenylcarbamoylated derivatives were chemically bonded onto vinylized silica using a radical co-polymerization reaction. The derived materials were used as chiral stationary phases (CSP) in supercritical fluid chromatography (SFC). Enantioseparations were successfully demonstrated on 14 racemates encompassing flavanones, thiazides and amino acid derivatives. The electrostatic force between the analytes and the cationic moiety on β-CD derivative was found to be important for retention and enantioseparation of the racemates. Aromatic cationic moiety on β-CD enabled better enantioseparations than aliphatic cationic moiety. It was also found that the presence of acid additives would result in lower retention of the analytes but often assist the chiral resolutions. 2013-07-16T09:04:09Z 2019-12-06T19:36:44Z 2013-07-16T09:04:09Z 2019-12-06T19:36:44Z 2011 2011 Journal Article Wang, R.-Q., Ong, T.-T., & Ng, S.-C. (2012). Chemically bonded cationic β-cyclodextrin derivatives and their applications in supercritical fluid chromatography. Journal of Chromatography A, 1224, 97-103. 0021-9673 https://hdl.handle.net/10356/96928 http://hdl.handle.net/10220/11622 10.1016/j.chroma.2011.12.053 en Journal of chromatography A © 2011 Elsevier B.V. |
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DRNTU::Engineering::Chemical engineering Wang, Ren-Qi Ong, Teng-Teng Ng, Siu-Choon Chemically bonded cationic β-cyclodextrin derivatives and their applications in supercritical fluid chromatography |
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Cationic β-cyclodextrin (CD) perphenylcarbamoylated derivatives were chemically bonded onto vinylized silica using a radical co-polymerization reaction. The derived materials were used as chiral stationary phases (CSP) in supercritical fluid chromatography (SFC). Enantioseparations were successfully demonstrated on 14 racemates encompassing flavanones, thiazides and amino acid derivatives. The electrostatic force between the analytes and the cationic moiety on β-CD derivative was found to be important for retention and enantioseparation of the racemates. Aromatic cationic moiety on β-CD enabled better enantioseparations than aliphatic cationic moiety. It was also found that the presence of acid additives would result in lower retention of the analytes but often assist the chiral resolutions. |
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School of Chemical and Biomedical Engineering |
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School of Chemical and Biomedical Engineering Wang, Ren-Qi Ong, Teng-Teng Ng, Siu-Choon |
format |
Article |
author |
Wang, Ren-Qi Ong, Teng-Teng Ng, Siu-Choon |
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Wang, Ren-Qi |
title |
Chemically bonded cationic β-cyclodextrin derivatives and their applications in supercritical fluid chromatography |
title_short |
Chemically bonded cationic β-cyclodextrin derivatives and their applications in supercritical fluid chromatography |
title_full |
Chemically bonded cationic β-cyclodextrin derivatives and their applications in supercritical fluid chromatography |
title_fullStr |
Chemically bonded cationic β-cyclodextrin derivatives and their applications in supercritical fluid chromatography |
title_full_unstemmed |
Chemically bonded cationic β-cyclodextrin derivatives and their applications in supercritical fluid chromatography |
title_sort |
chemically bonded cationic β-cyclodextrin derivatives and their applications in supercritical fluid chromatography |
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2013 |
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https://hdl.handle.net/10356/96928 http://hdl.handle.net/10220/11622 |
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1681035508545748992 |