Sustained delivery of a novel natriuretic peptide for three weeks with in situ polymer precipitation delivery system

• Main Authors: Lim, Soo G., Ameenuddin, Syed, Burnett Jr, John C., Venkatraman, Subbu S., Chen, Horng H.
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Chemistry::Organic chemistry::Polymers
• Online Access: https://hdl.handle.net/10356/96935; http://hdl.handle.net/10220/9976
• Institution: Nanyang Technological University

CD-NP (Cenderitide) is a chimeric natriuretic peptide that acts on both the A and B natriuretic guanylyl cylcase receptors. This differentiated mechanism of action avoids the hypotensive nature of BNP while retaining the cardiac unloading and renal enhancing actions in heart failure (HF) together wi...