Multifunctional mesoporous silica nanoparticles for cancer-targeted and controlled drug delivery
Multifunctional mesoporous silica nanoparticles are developed in order to deliver anticancer drugs to specific cancer cells in a targeted and controlled manner. The nanoparticle surface is functionalized with amino-β-cyclodextrin rings bridged by cleavable disulfide bonds, blocking drugs inside the...
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sg-ntu-dr.10356-970842020-06-01T10:21:08Z Multifunctional mesoporous silica nanoparticles for cancer-targeted and controlled drug delivery Zhang, Quan Liu, Fang Nguyen, Kim Truc Ma, Xing Wang, Xiao-Jun Xing, Bengang Zhao, Yanli School of Materials Science & Engineering School of Physical and Mathematical Sciences Multifunctional mesoporous silica nanoparticles are developed in order to deliver anticancer drugs to specific cancer cells in a targeted and controlled manner. The nanoparticle surface is functionalized with amino-β-cyclodextrin rings bridged by cleavable disulfide bonds, blocking drugs inside the mesopores of the nanoparticles. Poly(ethylene glycol) polymers, functionalized with an adamantane unit at one end and a folate unit at the other end, are immobilized onto the nanoparticle surface through strong β-cyclodextrin/adamantane complexation. The non-cytotoxic nanoparticles containing the folate targeting units are efficiently trapped by folate-receptor-rich HeLa cancer cells through receptormmediated endocytosis, while folate-receptor-poor human embryonic kidney 293 normal cells show much lower endocytosis towards nanoparticles under the same conditions. The nanoparticles endocytosed by the cancer cells can release loaded doxorubicin into the cells triggered by acidic endosomal pH. After the nanoparticles escape from the endosome and enter into the cytoplasm of cancer cells, the high concentration of glutathione in the cytoplasm can lead to the removal of the β-cyclodextrin capping rings by cleaving the pre-installed disulfide bonds, further promoting the release of doxorubicin from the drug carriers. The high drug-delivery efficacy of the multifunctional nanoparticles is attributed to the co-operative effects of folate-mediated targeting and stimuli-triggered drug release. The present delivery system capable of delivering drugs in a targeted and controlled manner provides a novel platform for the next generation of therapeutics 2013-06-17T02:45:28Z 2019-12-06T19:38:49Z 2013-06-17T02:45:28Z 2019-12-06T19:38:49Z 2012 2012 Journal Article Zhang, Q., Liu, F., Nguyen, K. T., Ma, X., Wang, X., Xing, B., et al. (2012). Multifunctional Mesoporous Silica Nanoparticles for Cancer-Targeted and Controlled Drug Delivery. Advanced Functional Materials, 22(24), 5144-5156. 1616-3028 https://hdl.handle.net/10356/97084 http://hdl.handle.net/10220/10413 10.1002/adfm.201201316 en Advanced functional materials © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. |
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Multifunctional mesoporous silica nanoparticles are developed in order to deliver anticancer drugs to specific cancer cells in a targeted and controlled manner. The nanoparticle surface is functionalized with amino-β-cyclodextrin rings bridged by cleavable disulfide bonds, blocking drugs inside the mesopores of the nanoparticles. Poly(ethylene glycol) polymers, functionalized with an adamantane unit at one end and a folate unit at the other end, are immobilized onto the nanoparticle surface through strong β-cyclodextrin/adamantane complexation. The non-cytotoxic nanoparticles containing the folate targeting units are efficiently trapped by folate-receptor-rich HeLa cancer cells through receptormmediated endocytosis, while folate-receptor-poor human embryonic kidney 293 normal cells show much lower endocytosis towards nanoparticles under the same conditions. The nanoparticles endocytosed by the cancer cells can release loaded doxorubicin into the cells triggered by acidic endosomal pH. After the nanoparticles escape from the endosome and enter into the cytoplasm of cancer cells, the high concentration of glutathione in the cytoplasm can lead to the removal of the β-cyclodextrin capping rings by cleaving the pre-installed disulfide bonds, further promoting the release of doxorubicin from the drug carriers. The high drug-delivery efficacy of the multifunctional nanoparticles is attributed to the co-operative effects of folate-mediated targeting and stimuli-triggered drug release. The present delivery system capable of delivering drugs in a targeted and controlled manner provides a novel platform for the next generation of therapeutics |
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School of Materials Science & Engineering |
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School of Materials Science & Engineering Zhang, Quan Liu, Fang Nguyen, Kim Truc Ma, Xing Wang, Xiao-Jun Xing, Bengang Zhao, Yanli |
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Article |
author |
Zhang, Quan Liu, Fang Nguyen, Kim Truc Ma, Xing Wang, Xiao-Jun Xing, Bengang Zhao, Yanli |
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Zhang, Quan Liu, Fang Nguyen, Kim Truc Ma, Xing Wang, Xiao-Jun Xing, Bengang Zhao, Yanli Multifunctional mesoporous silica nanoparticles for cancer-targeted and controlled drug delivery |
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Zhang, Quan |
title |
Multifunctional mesoporous silica nanoparticles for cancer-targeted and controlled drug delivery |
title_short |
Multifunctional mesoporous silica nanoparticles for cancer-targeted and controlled drug delivery |
title_full |
Multifunctional mesoporous silica nanoparticles for cancer-targeted and controlled drug delivery |
title_fullStr |
Multifunctional mesoporous silica nanoparticles for cancer-targeted and controlled drug delivery |
title_full_unstemmed |
Multifunctional mesoporous silica nanoparticles for cancer-targeted and controlled drug delivery |
title_sort |
multifunctional mesoporous silica nanoparticles for cancer-targeted and controlled drug delivery |
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2013 |
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https://hdl.handle.net/10356/97084 http://hdl.handle.net/10220/10413 |
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