Controlled β-protonation and [4+2] cycloaddition of enals and chalcones via N-heterocyclic carbene/acid catalysis : toward substrate independent reaction control

• Main Authors: Fu, Zhenqian, Sun, Hui, Chen, Shaojin, Tiwari, Bhoopendra, Li, Guohui, Chi, Robin Yonggui
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2013
• Online Access: https://hdl.handle.net/10356/97255; http://hdl.handle.net/10220/10471
• Institution: Nanyang Technological University

A substrate-independent selective generation of enolates over homoenolate equivalents in NHC-catalyzed reactions of enals and chalcones is disclosed. Acid co-catalysts play vital roles in control of the reaction pathways, allowing for individual access to diverse products from identical substrates.