Identifying DNA motifs based on match and mismatch alignment information

Identifying DNA motifs based on match and mismatch alignment information

The conventional way of identifying DNA motifs, solely based on match alignment information, is susceptible to a high number of spurious sites. A novel scoring system has been introduced by taking both match and mismatch alignment information into account. The mismatch alignment information is usefu...

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Main Authors: Shu, Jian Jun, Yong, Kian Yan
Other Authors: School of Mechanical and Aerospace Engineering
Format: Article
Language:English
Published: 2013
Online Access:https://hdl.handle.net/10356/97295
http://hdl.handle.net/10220/13243
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-972952023-03-04T17:18:55Z Identifying DNA motifs based on match and mismatch alignment information Shu, Jian Jun Yong, Kian Yan School of Mechanical and Aerospace Engineering The conventional way of identifying DNA motifs, solely based on match alignment information, is susceptible to a high number of spurious sites. A novel scoring system has been introduced by taking both match and mismatch alignment information into account. The mismatch alignment information is useful to remove spurious sites encountered in DNA motif searching. As an example, a correct TATA box site in Homo sapiensH4/g gene has successfully been identified based on match and mismatch alignment information. Accepted version 2013-08-27T06:44:06Z 2019-12-06T19:41:01Z 2013-08-27T06:44:06Z 2019-12-06T19:41:01Z 2013 2013 Journal Article Shu, J. J., & Yong, K. Y. (2013). Identifying DNA motifs based on match and mismatch alignment information. Journal of Mathematical Chemistry, 51(7), 1720-1728. 0259-9791 https://hdl.handle.net/10356/97295 http://hdl.handle.net/10220/13243 10.1007/s10910-013-0175-2 170063 en Journal of mathematical chemistry © 2013 Springer Science+Business Media New York. This is the author created version of a work that has been peer reviewed and accepted for publication by Journal of Mathematical Chemistry, Springer Science+Business Media New York. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1007/s10910-013-0175-2]. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
description The conventional way of identifying DNA motifs, solely based on match alignment information, is susceptible to a high number of spurious sites. A novel scoring system has been introduced by taking both match and mismatch alignment information into account. The mismatch alignment information is useful to remove spurious sites encountered in DNA motif searching. As an example, a correct TATA box site in Homo sapiensH4/g gene has successfully been identified based on match and mismatch alignment information.
author2 School of Mechanical and Aerospace Engineering
author_facet School of Mechanical and Aerospace Engineering
Shu, Jian Jun
Yong, Kian Yan
format Article
author Shu, Jian Jun
Yong, Kian Yan
spellingShingle Shu, Jian Jun
Yong, Kian Yan
Identifying DNA motifs based on match and mismatch alignment information
author_sort Shu, Jian Jun
title Identifying DNA motifs based on match and mismatch alignment information
title_short Identifying DNA motifs based on match and mismatch alignment information
title_full Identifying DNA motifs based on match and mismatch alignment information
title_fullStr Identifying DNA motifs based on match and mismatch alignment information
title_full_unstemmed Identifying DNA motifs based on match and mismatch alignment information
title_sort identifying dna motifs based on match and mismatch alignment information
publishDate 2013
url https://hdl.handle.net/10356/97295
http://hdl.handle.net/10220/13243
_version_ 1759854164017414144

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