Oxidative γ-addition of enals to trifluoromethyl ketones : enantioselectivity control via Lewis acid/N-heterocyclic carbene cooperative catalysis
An oxidative γ-functionalization of enals under N-heterocyclic carbene (NHC) catalysis to give unsaturated δ-lactones is disclosed. Enantioselectivity control involving the relatively remote enal γ-carbon was achieved via Lewis acid [Sc(OTf)3 or combined Sc(OTf)3/Mg(OTf)2] and NHC cooperative cataly...
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sg-ntu-dr.10356-976512020-03-07T12:31:27Z Oxidative γ-addition of enals to trifluoromethyl ketones : enantioselectivity control via Lewis acid/N-heterocyclic carbene cooperative catalysis Mo, Junming Chen, Xingkuan Chi, Robin Yonggui School of Physical and Mathematical Sciences An oxidative γ-functionalization of enals under N-heterocyclic carbene (NHC) catalysis to give unsaturated δ-lactones is disclosed. Enantioselectivity control involving the relatively remote enal γ-carbon was achieved via Lewis acid [Sc(OTf)3 or combined Sc(OTf)3/Mg(OTf)2] and NHC cooperative catalysis. 2013-07-12T01:25:16Z 2019-12-06T19:44:57Z 2013-07-12T01:25:16Z 2019-12-06T19:44:57Z 2012 2012 Journal Article Mo, J., Chen, X., & Chi, Y. R. (2012). Oxidative γ-Addition of Enals to Trifluoromethyl Ketones: Enantioselectivity Control via Lewis Acid/N-Heterocyclic Carbene Cooperative Catalysis. Journal of the American Chemical Society, 134(21), 8810-8813. https://hdl.handle.net/10356/97651 http://hdl.handle.net/10220/11248 10.1021/ja303618z 173625 en Journal of the American chemical society © 2012 American Chemical Society. |
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An oxidative γ-functionalization of enals under N-heterocyclic carbene (NHC) catalysis to give unsaturated δ-lactones is disclosed. Enantioselectivity control involving the relatively remote enal γ-carbon was achieved via Lewis acid [Sc(OTf)3 or combined Sc(OTf)3/Mg(OTf)2] and NHC cooperative catalysis. |
| author2 |
School of Physical and Mathematical Sciences |
| author_facet |
School of Physical and Mathematical Sciences Mo, Junming Chen, Xingkuan Chi, Robin Yonggui |
| format |
Article |
| author |
Mo, Junming Chen, Xingkuan Chi, Robin Yonggui |
| spellingShingle |
Mo, Junming Chen, Xingkuan Chi, Robin Yonggui Oxidative γ-addition of enals to trifluoromethyl ketones : enantioselectivity control via Lewis acid/N-heterocyclic carbene cooperative catalysis |
| author_sort |
Mo, Junming |
| title |
Oxidative γ-addition of enals to trifluoromethyl ketones : enantioselectivity control via Lewis acid/N-heterocyclic carbene cooperative catalysis |
| title_short |
Oxidative γ-addition of enals to trifluoromethyl ketones : enantioselectivity control via Lewis acid/N-heterocyclic carbene cooperative catalysis |
| title_full |
Oxidative γ-addition of enals to trifluoromethyl ketones : enantioselectivity control via Lewis acid/N-heterocyclic carbene cooperative catalysis |
| title_fullStr |
Oxidative γ-addition of enals to trifluoromethyl ketones : enantioselectivity control via Lewis acid/N-heterocyclic carbene cooperative catalysis |
| title_full_unstemmed |
Oxidative γ-addition of enals to trifluoromethyl ketones : enantioselectivity control via Lewis acid/N-heterocyclic carbene cooperative catalysis |
| title_sort |
oxidative γ-addition of enals to trifluoromethyl ketones : enantioselectivity control via lewis acid/n-heterocyclic carbene cooperative catalysis |
| publishDate |
2013 |
| url |
https://hdl.handle.net/10356/97651 http://hdl.handle.net/10220/11248 |
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1681042052290183168 |