Titanium dioxide nanomaterials cause endothelial cell leakiness by disrupting the homophilic interaction of VE–cadherin

• Main Authors: Tay, Chor Yong, Chong, Han Chung, Loo, Say Chye Joachim, Leong, David Tai Wei, Fang, W., Setyawati, M. I., Chia, S. L., Goh, S. L., Neo, M. J., Tan, S.M., Ng, K. W., Xie, J. P., Ong, C. N., Tan, N. S.
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Engineering::Materials::Nanostructured materials
• Online Access: https://hdl.handle.net/10356/97752; http://hdl.handle.net/10220/18159
• Institution: Nanyang Technological University

The use of nanomaterials has raised safety concerns, as their small size facilitates accumulation in and interaction with biological tissues. Here we show that exposure of endothelial cells to TiO2 nanomaterials causes endothelial cell leakiness. This effect is caused by the physical interaction bet...