Cutting edge : synchronization of IRF1, JunB, and C/EBP activities during TLR3-TLR7 cross-talk orchestrates timely cytokine synergy in the proinflammatory response

• Main Authors: Yong, Wai Khang, Sze, Newman Siu Kwan, Tan, Nguan Soon, Liu, Qian, Zhu, Yong, Ding, Jeak Ling
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences::Microbiology::Bacteria
• Online Access: https://hdl.handle.net/10356/97885; http://hdl.handle.net/10220/38510
• Institution: Nanyang Technological University

Multiple pathogen-associated molecular pattern–induced TLR pathway cross-talk provokes proinflammatory cytokine synergy in macrophages, which is important for pathogen resistance and immune homeostasis. However, the detailed mechanisms are unclear. In this article, we demonstrate viral RNA analog–in...