Progressive dry-core-wet-rim hydration trend in a nested-ring topology of protein binding interfaces

• Main Authors: Li, Zhenhua, He, Ying, Wong, Limsoon, Li, Jinyan
• Other Authors: School of Computer Engineering
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Engineering::Computer science and engineering
• Online Access: https://hdl.handle.net/10356/97902; http://hdl.handle.net/10220/10889
• Institution: Nanyang Technological University

Background: Water is an integral part of protein complexes. It shapes protein binding sites by filling cavities and it bridges local contacts by hydrogen bonds. However, water molecules are usually not included in protein interface models in the past, and few distribution profiles of water molecules...