Progressive dry-core-wet-rim hydration trend in a nested-ring topology of protein binding interfaces

• المؤلفون الرئيسيون: Li, Zhenhua, He, Ying, Wong, Limsoon, Li, Jinyan
• مؤلفون آخرون: School of Computer Engineering
• التنسيق: مقال
• اللغة: English
• منشور في: 2013
• الموضوعات: DRNTU::Engineering::Computer science and engineering
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/97902; http://hdl.handle.net/10220/10889
• المؤسسة: Nanyang Technological University

Background: Water is an integral part of protein complexes. It shapes protein binding sites by filling cavities and it bridges local contacts by hydrogen bonds. However, water molecules are usually not included in protein interface models in the past, and few distribution profiles of water molecules...