Structural basis for promiscuity and specificity during Candida glabrata invasion of host epithelia

• Main Authors: Maestre-Reyna, M., Diderrich, R., Veelders, M. S., Eulenburg, G., Kalugin, V., Brückner, S., Keller, P., Rupp, S., Mösch, H.-U., Essen, L.-O.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/97909; http://hdl.handle.net/10220/12333
• Institution: Nanyang Technological University

The human pathogenic yeast Candida glabrata harbors more than 20 surface-exposed, epithelial adhesins (Epas) for host cell adhesion. The Epa family recognizes host glycans and discriminates between target tissues by their adhesin (A) domains, but a detailed structural basis for ligand-binding specif...