Molecular dynamics simulation study on the molecular structures of the amylin fibril models

• المؤلفون الرئيسيون: Xu, Weixin, Su, Haibin, Mu, Yuguang, Zhang, John Z. H.
• مؤلفون آخرون: School of Materials Science & Engineering
• التنسيق: مقال
• اللغة: English
• منشور في: 2013
• الموضوعات: DRNTU::Science::Chemistry::Physical chemistry
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/97982; http://hdl.handle.net/10220/17172
• المؤسسة: Nanyang Technological University

The structural characterization of amyloid fibers is one of the most investigated areas in structural biology. Recently, protofibril models for amylin, i.e., the 37-residue human islet amyloid polypeptide or hIAPP were suggested by two groups based on NMR ( Biochemistry 2007, 46, 13505−13522) and X-...