Structure of a novel phosphotyrosine-binding domain in Hakai that targets E-cadherin

• المؤلفون الرئيسيون: Mukherjee, Manjeet, Chow, Soah Yee, Yusoff, Permeen, Seetharaman, J., Ng, Cherlyn, Sinniah, Saravanan, Koh, Xiao Woon, Asgar, Nur Farehan M., Li, Dan, Yim, Daniel, Jackson, Rebecca A., Yew, Jingxi, Qian, Jingru, Iyu, Audrey, Lim, Yoon Pin, Zhou, Xingding, Sze, Siu Kwan, Guy, Graeme R., Sivaraman, J.
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2013
• الموضوعات: DRNTU::Science::Biological sciences
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/98086; http://hdl.handle.net/10220/13290

Phosphotyrosine-binding domains, typified by the SH2 (Src homology 2) and PTB domains, are critical upstream components of signal transduction pathways. The E3 ubiquitin ligase Hakai targets tyrosine-phosphorylated E-cadherin via an uncharacterized domain. In this study, the crystal structure of Hak...