Structure of a novel phosphotyrosine-binding domain in Hakai that targets E-cadherin

• Main Authors: Mukherjee, Manjeet, Chow, Soah Yee, Yusoff, Permeen, Seetharaman, J., Ng, Cherlyn, Sinniah, Saravanan, Koh, Xiao Woon, Asgar, Nur Farehan M., Li, Dan, Yim, Daniel, Jackson, Rebecca A., Yew, Jingxi, Qian, Jingru, Iyu, Audrey, Lim, Yoon Pin, Zhou, Xingding, Sze, Siu Kwan, Guy, Graeme R., Sivaraman, J.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/98086; http://hdl.handle.net/10220/13290
• Institution: Nanyang Technological University

Phosphotyrosine-binding domains, typified by the SH2 (Src homology 2) and PTB domains, are critical upstream components of signal transduction pathways. The E3 ubiquitin ligase Hakai targets tyrosine-phosphorylated E-cadherin via an uncharacterized domain. In this study, the crystal structure of Hak...