Plasmin triggers a switch-like decrease in thrombospondin-dependent activation of TGF-β1

• Main Authors: Venkatraman, Lakshmi, Chia, Ser-Mien, White, Jacob K., Bhowmick, Sourav S., So, Peter T., Narmada, Balakrishnan Chakrapani, Dewey Jr., C. Forbes, Tucker-Kellogg, Lisa, Yu, Hanry
• Other Authors: School of Computer Engineering
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Engineering::Computer science and engineering
• Online Access: https://hdl.handle.net/10356/98087; http://hdl.handle.net/10220/10784
• Institution: Nanyang Technological University

Transforming growth factor-β1 (TGF-β1) is a potent regulator of extracellular matrix production, wound healing, differentiation, and immune response, and is implicated in the progression of fibrotic diseases and cancer. Extracellular activation of TGF-β1 from its latent form provides spatiotemporal...