Nuclear deformation during breast cancer cell transmigration

• Main Authors: VanDongen, Antonius M. J., Fu, Yi, Chin, Lip Ket, Bourouina, Tarik, Liu, Ai Qin
• Other Authors: School of Electrical and Electronic Engineering
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Medicine::Biomedical engineering
• Online Access: https://hdl.handle.net/10356/98194; http://hdl.handle.net/10220/17548
• Institution: Nanyang Technological University

Metastasis is the main cause of cancer mortality. During this process, cancer cells dislodge from a primary tumor, enter the circulation and form secondary tumors in distal organs. It is poorly understood how these cells manage to cross the tight syncytium of endothelial cells that lines the capilla...