Identification of atrogin-1-targeted proteins during the myostatin-induced skeletal muscle wasting

• المؤلفون الرئيسيون: Lokireddy, Sudarsanareddy, Wijesoma, Isuru Wijerupage, Sze, Siu Kwan, McFarlane, Craig, Kambadur, Ravi, Sharma, Mridula
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2013
• الموضوعات: DRNTU::Science::Biological sciences
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/98278; http://hdl.handle.net/10220/12435
• المؤسسة: Nanyang Technological University

Atrogin-1, a muscle-specific E3 ligase, targets MyoD for degradation through the ubiquitin-proteasome-mediated system. Myostatin, a member of the transforming growth factor-β superfamily, potently inhibits myogenesis by lowering MyoD levels. While atrogin-1 is upregulated by myostatin, it is current...