Direct asymmetric allylic alkenylation of N-itaconimides with Morita–Baylis–Hillman carbonates

The asymmetric allylic alkenylation of Morita–Baylis–Hillman (MBH) carbonates with N-itaconimides as nucleophiles has been developed using a commercially available Cinchona alkaloid catalyst. A variety of multifunctional chiral α-methylene-β-maleimide esters were attained in moderate to excellent yi...

Full description

Saved in:
Bibliographic Details
Main Authors: Yang, Wenguo, Tan, Davin, Li, Lixin, Han, Zhiqiang, Yan, Lin, Huang, Kuo-Wei, Tan, Choon-Hong, Jiang, Zhiyong
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2013
Online Access:https://hdl.handle.net/10356/98322
http://hdl.handle.net/10220/17040
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Nanyang Technological University
Language: English
id sg-ntu-dr.10356-98322
record_format dspace
spelling sg-ntu-dr.10356-983222020-03-07T12:34:46Z Direct asymmetric allylic alkenylation of N-itaconimides with Morita–Baylis–Hillman carbonates Yang, Wenguo Tan, Davin Li, Lixin Han, Zhiqiang Yan, Lin Huang, Kuo-Wei Tan, Choon-Hong Jiang, Zhiyong School of Physical and Mathematical Sciences The asymmetric allylic alkenylation of Morita–Baylis–Hillman (MBH) carbonates with N-itaconimides as nucleophiles has been developed using a commercially available Cinchona alkaloid catalyst. A variety of multifunctional chiral α-methylene-β-maleimide esters were attained in moderate to excellent yields (up to 99%) and good to excellent enantioselectivities (up to 91% ee). The origin of the regio- and stereoselectivity was verified by DFT methods. Calculated geometries and relative energies of various transition states strongly support the observed regio- and enantioselectivity. 2013-10-30T04:11:47Z 2019-12-06T19:53:33Z 2013-10-30T04:11:47Z 2019-12-06T19:53:33Z 2012 2012 Journal Article Yang, W., Tan, D., Li, L., Han, Z., Yan, L., Huang, K.-W., et al. (2012). Direct Asymmetric Allylic Alkenylation of N -Itaconimides with Morita–Baylis–Hillman Carbonates . The Journal of Organic Chemistry, 77(15), 6600-6607. https://hdl.handle.net/10356/98322 http://hdl.handle.net/10220/17040 10.1021/jo3012539 en The journal of organic chemistry
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
description The asymmetric allylic alkenylation of Morita–Baylis–Hillman (MBH) carbonates with N-itaconimides as nucleophiles has been developed using a commercially available Cinchona alkaloid catalyst. A variety of multifunctional chiral α-methylene-β-maleimide esters were attained in moderate to excellent yields (up to 99%) and good to excellent enantioselectivities (up to 91% ee). The origin of the regio- and stereoselectivity was verified by DFT methods. Calculated geometries and relative energies of various transition states strongly support the observed regio- and enantioselectivity.
author2 School of Physical and Mathematical Sciences
author_facet School of Physical and Mathematical Sciences
Yang, Wenguo
Tan, Davin
Li, Lixin
Han, Zhiqiang
Yan, Lin
Huang, Kuo-Wei
Tan, Choon-Hong
Jiang, Zhiyong
format Article
author Yang, Wenguo
Tan, Davin
Li, Lixin
Han, Zhiqiang
Yan, Lin
Huang, Kuo-Wei
Tan, Choon-Hong
Jiang, Zhiyong
spellingShingle Yang, Wenguo
Tan, Davin
Li, Lixin
Han, Zhiqiang
Yan, Lin
Huang, Kuo-Wei
Tan, Choon-Hong
Jiang, Zhiyong
Direct asymmetric allylic alkenylation of N-itaconimides with Morita–Baylis–Hillman carbonates
author_sort Yang, Wenguo
title Direct asymmetric allylic alkenylation of N-itaconimides with Morita–Baylis–Hillman carbonates
title_short Direct asymmetric allylic alkenylation of N-itaconimides with Morita–Baylis–Hillman carbonates
title_full Direct asymmetric allylic alkenylation of N-itaconimides with Morita–Baylis–Hillman carbonates
title_fullStr Direct asymmetric allylic alkenylation of N-itaconimides with Morita–Baylis–Hillman carbonates
title_full_unstemmed Direct asymmetric allylic alkenylation of N-itaconimides with Morita–Baylis–Hillman carbonates
title_sort direct asymmetric allylic alkenylation of n-itaconimides with morita–baylis–hillman carbonates
publishDate 2013
url https://hdl.handle.net/10356/98322
http://hdl.handle.net/10220/17040
_version_ 1681037073662869504