Functional mesoporous silica nanoparticles for photothermal-controlled drug delivery in vivo

• Main Authors: Yan, Hong, Teh, Cathleen, Sreejith, Sivaramapanicker, Zhu, Liangliang, Kwok, Anna, Fang, Weiqin, Ma, Xing, Nguyen, Kim Truc, Korzh, Vladimir, Zhao, Yanli
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Engineering::Materials
• Online Access: https://hdl.handle.net/10356/98325; http://hdl.handle.net/10220/12452
• Institution: Nanyang Technological University

Release me! A new class of photothermal-responsive [2]rotaxane-appended mesoporous silica nanoparticles (MSNPs) was developed. Remote-controlled movement of the α-cyclodextrin ring (green) upon trans–cis isomerization of the azobenzene axle (red) enables the loading and release of drugs on demand (see scheme). Curcumin-loaded MSNPs were shown to release curcumin into zebrafish larvae upon treatment with visible light or heat.