Intermolecular Mizoroki-Heck reaction of aliphatic olefins with high selectivity for substitution at the internal position

Intermolecular Mizoroki-Heck reaction of aliphatic olefins with high selectivity for substitution at the internal position

New ligand for old reaction: The title reaction of aryltriflates with aliphatic olefins leads to substitution at the internal position with high selectivity. The ratio of the desired isomer (shown in the scheme) to the sum of all other isomers is generally above 10:1. The key to success is the use o...

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Main Authors: Lu, Yunpeng, Li, Yongxin, Zhou, Jianrong Steve, Qin, Liena, Ren, Xinfeng
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2013
Online Access:https://hdl.handle.net/10356/98452
http://hdl.handle.net/10220/12466
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-984522020-03-07T12:34:47Z Intermolecular Mizoroki-Heck reaction of aliphatic olefins with high selectivity for substitution at the internal position Lu, Yunpeng Li, Yongxin Zhou, Jianrong Steve Qin, Liena Ren, Xinfeng School of Physical and Mathematical Sciences New ligand for old reaction: The title reaction of aryltriflates with aliphatic olefins leads to substitution at the internal position with high selectivity. The ratio of the desired isomer (shown in the scheme) to the sum of all other isomers is generally above 10:1. The key to success is the use of a ferrocene bisphosphine ligand (R= 1-naphthyl). The reaction can be easily scaled up, and minor isomers can be separated by chromatography. 2013-07-29T06:47:46Z 2019-12-06T19:55:23Z 2013-07-29T06:47:46Z 2019-12-06T19:55:23Z 2012 2012 Journal Article Qin, L., Ren, X., Lu, Y., Li, Y., & Zhou, J. S. (2012). Intermolecular Mizoroki-Heck Reaction of Aliphatic Olefins with High Selectivity for Substitution at the Internal Position. Angewandte Chemie International Edition, 51(24), 5915-5919. 1433-7851 https://hdl.handle.net/10356/98452 http://hdl.handle.net/10220/12466 10.1002/anie.201201806 en Angewandte chemie international edition © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
description New ligand for old reaction: The title reaction of aryltriflates with aliphatic olefins leads to substitution at the internal position with high selectivity. The ratio of the desired isomer (shown in the scheme) to the sum of all other isomers is generally above 10:1. The key to success is the use of a ferrocene bisphosphine ligand (R= 1-naphthyl). The reaction can be easily scaled up, and minor isomers can be separated by chromatography.
author2 School of Physical and Mathematical Sciences
author_facet School of Physical and Mathematical Sciences
Lu, Yunpeng
Li, Yongxin
Zhou, Jianrong Steve
Qin, Liena
Ren, Xinfeng
format Article
author Lu, Yunpeng
Li, Yongxin
Zhou, Jianrong Steve
Qin, Liena
Ren, Xinfeng
spellingShingle Lu, Yunpeng
Li, Yongxin
Zhou, Jianrong Steve
Qin, Liena
Ren, Xinfeng
Intermolecular Mizoroki-Heck reaction of aliphatic olefins with high selectivity for substitution at the internal position
author_sort Lu, Yunpeng
title Intermolecular Mizoroki-Heck reaction of aliphatic olefins with high selectivity for substitution at the internal position
title_short Intermolecular Mizoroki-Heck reaction of aliphatic olefins with high selectivity for substitution at the internal position
title_full Intermolecular Mizoroki-Heck reaction of aliphatic olefins with high selectivity for substitution at the internal position
title_fullStr Intermolecular Mizoroki-Heck reaction of aliphatic olefins with high selectivity for substitution at the internal position
title_full_unstemmed Intermolecular Mizoroki-Heck reaction of aliphatic olefins with high selectivity for substitution at the internal position
title_sort intermolecular mizoroki-heck reaction of aliphatic olefins with high selectivity for substitution at the internal position
publishDate 2013
url https://hdl.handle.net/10356/98452
http://hdl.handle.net/10220/12466
_version_ 1681040772331208704

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