p53-independent regulation of p21Waf1/Cip1 expression and senescence by PRMT6

• Main Authors: Phalke, Sameer, Mzoughi, Slim, Bezzi, Marco, Jennifer, Nancy, Mok, Wei Chuen, Thike, Aye Aye, Tan, Puay Hoon, Voorhoeve, P. Mathijs, Guccione, Ernesto, Low, Diana H. P., Kuznetsov, Vladimir A.
• Other Authors: School of Computer Engineering
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Engineering::Computer science and engineering
• Online Access: https://hdl.handle.net/10356/98603; http://hdl.handle.net/10220/10920
• Institution: Nanyang Technological University

p21 is a potent cyclin-dependent kinase inhibitor that plays a role in promoting G1 cell cycle arrest and cellular senescence. Consistent with this role, p21 is a downstream target of several tumour suppressors and oncogenes, and it is downregulated in the majority of tumours, including breast cance...