The N-terminal acetylation of Sir3 stabilizes its binding to the nucleosome core particle

• Main Authors: Arnaudo, Nadia, Rhodes, Daniela, Martino, Fabrizio, Fernández, Israel S., McLaughlin, Stephen H., Peak-Chew, Sew Y.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences::Molecular biology
• Online Access: https://hdl.handle.net/10356/98638; http://hdl.handle.net/10220/17646
• Institution: Nanyang Technological University

The N-terminal acetylation of Sir3 is essential for heterochromatin establishment and maintenance in yeast, but its mechanism of action is unknown. The crystal structure of the N-terminally acetylated BAH domain of Saccharomyces cerevisiae Sir3 bound to the nucleosome core particle reveals that the...