An in silico erythropoiesis model rationalizing synergism between stem cell factor and erythropoietin

• Main Authors: Phan, Tran Hong Ha, Saraf, Pritha, Kiparissides, Alexandros, Song, Hao, Lim, Mayasari, Mantalaris, Athanasios (Sakis)
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Engineering::Bioengineering
• Online Access: https://hdl.handle.net/10356/98640; http://hdl.handle.net/10220/17446
• Institution: Nanyang Technological University

Stem cell factor (SCF) and erythropoietin (EPO) are two most recognized growth factors that play in concert to control in vitro erythropoiesis. However, exact mechanisms underlying the interplay of these growth factors in vitro remain unclear. We developed a mathematical model to study co-signaling...