Z-score biological significance of binding hot spots of protein interfaces by using crystal packing as the reference state

• Main Authors: Liu, Qian, Wong, Limsoon, Li, Jinyan
• Other Authors: School of Computer Engineering
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Engineering::Computer science and engineering
• Online Access: https://hdl.handle.net/10356/98765; http://hdl.handle.net/10220/12723
• Institution: Nanyang Technological University

Characterization of binding hot spots of protein interfaces is a fundamental study in molecular biology. Many computational methods have been proposed to identify binding hot spots. However, there are few studies to assess the biological significance of binding hot spots. We introduce the notion of...