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  ____       ___     __   __    _____     _____   
 |  _ \\    / _ \\   \ \\/ //  |  ___||  /  ___|| 
 | |_| ||  / //\ \\   \   //   | ||__   | // __   
 | .  //  |  ___  ||  / . \\   | ||__   | \\_\ || 
 |_|\_\\  |_||  |_|| /_//\_\\  |_____||  \____//  
 `-` --`  `-`   `-`  `-`  --`  `-----`    `---`

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Text this: Z-score biological significance of binding hot spots of protein interfaces by using crystal packing as the reference state