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 __   _      ___      ____     _    _     ______  
| || | ||   / _ \\   |  _ \\  | || | ||  /_____// 
| '--' ||  | / \ ||  | |_| || | || | ||  `____ `  
| .--. ||  | \_/ ||  | .  //  | \\_/ ||  /___//   
|_|| |_||   \___//   |_|\_\\   \____//   `__ `    
`-`  `-`    `---`    `-` --`    `---`    /_//     
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Text this: Z-score biological significance of binding hot spots of protein interfaces by using crystal packing as the reference state