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 ______     ______    ____      ______    _____   
|      \\  /_   _//  |  _ \\   /_   _//  |__  //  
|  --  //   -| ||-   | |_| ||   -| ||-     / //   
|  --  \\   _| ||_   | .  //    _| ||_    / //__  
|______//  /_____//  |_|\_\\   /_____//  /_____|| 
`------`   `-----`   `-` --`   `-----`   `-----`

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Text this: Z-score biological significance of binding hot spots of protein interfaces by using crystal packing as the reference state