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 _    _      ___      ______   __   __   ______   
| \  / ||   / _ \\   /_____//  \ \\/ // |      \\ 
|  \/  ||  | / \ ||  `____ `    \ ` //  |  --  // 
| .  . ||  | \_/ ||  /___//      | ||   |  --  \\ 
|_|\/|_||   \___//   `__ `       |_||   |______// 
`-`  `-`    `---`    /_//        `-`'   `------`  
                     `-`

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Text this: Z-score biological significance of binding hot spots of protein interfaces by using crystal packing as the reference state