Z-score biological significance of binding hot spots of protein interfaces by using crystal packing as the reference state

• المؤلفون الرئيسيون: Liu, Qian, Wong, Limsoon, Li, Jinyan
• مؤلفون آخرون: School of Computer Engineering
• التنسيق: مقال
• اللغة: English
• منشور في: 2013
• الموضوعات: DRNTU::Engineering::Computer science and engineering
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/98765; http://hdl.handle.net/10220/12723
• المؤسسة: Nanyang Technological University

Characterization of binding hot spots of protein interfaces is a fundamental study in molecular biology. Many computational methods have been proposed to identify binding hot spots. However, there are few studies to assess the biological significance of binding hot spots. We introduce the notion of...