Structural requirements of salicylaldehyde benzoylhydrazones and their Cu(II) complexes for anticancer activity

• Main Authors: Tan, Shiow Jin, Sk, Mahasin Alam, Lee, Peter Peng Foo, Yan, Yaw Kai, Lim, Kok Hwa
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2013
• Online Access: https://hdl.handle.net/10356/99107; http://hdl.handle.net/10220/12775
• Institution: Nanyang Technological University

Salicylaldehyde benzoylhydrazone (H2sb) has a variety of biological activities including anticancer activity. The Cu(II) complexes of H2sbs possess enhanced anticancer activity as compared with their free ligands. A quantitative structure–activity relationship (QSAR) analysis was performed on a seri...