Systematic experimental design for bioprocess characterization: elucidating transient effects of multi-cytokine contributions on erythroid differentiation

• Main Authors: Lim, Mayasari, Shunjie, Chua, Panoskaltsis, Nicki, Mantalaris, Athanasios (Sakis)
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2013
• Online Access: https://hdl.handle.net/10356/99471; http://hdl.handle.net/10220/12708
• Institution: Nanyang Technological University

In vitro differentiation of hematopoietic stem cells (HSCs) is a highly dynamic process whereby contributions of exogenous cytokines vary at each stage of differentiation. In this study, we present erythroid differentiation as three progressive yet independent stages and aim to elucidate transient c...