Core structure-based design of Organocatalytic [3+2]-Cycloaddition reactions: highly efficient and Stereocontrolled Syntheses of 3,3′-Pyrrolidonyl Spirooxindoles

• Main Authors: Barbas III, Carlos F., Tan, Bin, Zeng, Xiaofei, Leong, Wendy Wen Yi, Shi, Zugui, Zhong, Guofu
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2013
• Online Access: https://hdl.handle.net/10356/99531; http://hdl.handle.net/10220/12896
• Institution: Nanyang Technological University

Extraordinary levels of stereocontrol were achieved in an efficient organocatalytic asymmetric [3+2]-cycloaddition reaction between an α-isothiocyanato imide and various methyleneindolinones. Simple precursors were used for the rapid construction of spirocyclic oxindole derivatives with high enantio...