Cobalt-catalyzed ortho-alkenylation of aromatic aldimines via chelation-assisted C–H bond activation

• Main Authors: Yamakawa, Takeshi, Yoshikai, Naohiko
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Chemistry::Organic chemistry
• Online Access: https://hdl.handle.net/10356/99588; http://hdl.handle.net/10220/17467
• Institution: Nanyang Technological University

An ortho-alkenylation reaction of an aromatic aldimine with an internal alkyne is efficiently promoted by a cobalt catalyst generated from CoBr2, triarylphosphine, and iPrMgBr. The reaction takes place under mild room-temperature conditions to afford, upon acidic hydrolysis, a variety of ortho-alken...