Nox4-dependent ROS modulation by amino endoperoxides to induce apoptosis in cancer cells

• Main Authors: Zhu, Pengcheng, Tong, Benny Meng Kiat, Wang, Runze, Chen, Jiapeng, Foo, Selin, Chong, Han Chung, Wang, Xiao Ling, Ang, Gim Yean, Chiba, Shunsuke, Tan, Nguan Soon
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences::Microbiology
• Online Access: https://hdl.handle.net/10356/99683; http://hdl.handle.net/10220/9452
• Institution: Nanyang Technological University

Tumor metastasis is the main cause of death in cancer patients. Anoikis resistance is one critical malefactor of metastatic cancer cells to resist current clinical chemotherapeutic treatments. Although endoperoxide-containing compounds have long been suggested as anticancer drugs, few have been clin...