Controlling fibrous capsule formation through long-term down-regulation of collagen type I (COL1A1) expression by nanofiber-mediated siRNA gene silencing

The foreign body reaction often interferes with the long-term functionality and performance of implanted biomedical devices through fibrous capsule formation. While many implant modification techniques have been adopted in attempts to control fibrous encapsulation, the outcomes remained sub-optimal....

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Bibliographic Details
Main Authors: Rujitanaroj, Pim-On, Jao, Brian, Yang, Junghoon, Wang, Feng, Anderson, James M., Wang, Jun, Chew, Sing Yian
Other Authors: School of Chemical and Biomedical Engineering
Format: Article
Language:English
Published: 2013
Subjects:
Online Access:https://hdl.handle.net/10356/99728
http://hdl.handle.net/10220/9960
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Institution: Nanyang Technological University
Language: English