T-cell death following immune activation is mediated by mitochondria-localized SARM

• Main Authors: Ho, B., Chen, J., Singh, L. P., Selvarajan, V., Ng, S. B., Tan, N. S., Panneerselvam, P., Chng, Wee Joo, Ding, Jeak Ling
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/99779; http://hdl.handle.net/10220/17575
• Institution: Nanyang Technological University

Following acute-phase infection, activated T cells are terminated to achieve immune homeostasis, failure of which results in lymphoproliferative and autoimmune diseases. We report that sterile α- and heat armadillo-motif-containing protein (SARM), the most conserved Toll-like receptors adaptor, is p...