Synthesis and antiproliferative activity of helonioside A, 3′,4′,6′-tri-O-feruloylsucrose, lapathoside C and their analogs

• Main Authors: Panda, Parthasarathi, Appalashetti, Manjuvani, Natarajan, Meenubharathi, Mary, Chan-Park, Venkatraman, Subbu S., Judeh, Zaher M. A.
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Engineering::Chemical engineering; DRNTU::Engineering::Materials
• Online Access: https://hdl.handle.net/10356/99846; http://hdl.handle.net/10220/13751
• Institution: Nanyang Technological University

The first total synthesis of natural phenylpropanoid sucrose esters (PSEs) helonioside A 1, 3′,4′,6′-tri-O-feruloylsucrose 2 and lapathoside C 3 along with 17 unnatural PSE analogs has been successfully accomplished in a short and simple synthetic route. A selected set of 17 synthesized PSEs were ev...