Focal targeting by human β-defensin 2 disrupts localized virulence factor assembly sites in Enterococcus faecalis

• Main Authors: Normark, Staffan, Kandaswamy, Kumaravel, Liew, Tze Horng, Huston-Warren, Emily, Meyer-Hoffert, Ulf, Hultenby, Kjell, Henriques-Normark, Birgitta, Wang, Charles Y., Schröder, Jens M., Caparon, Michael G., Hultgren, Scott J., Kline, Kimberly A.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences::Microbiology::Bacteria
• Online Access: https://hdl.handle.net/10356/99893; http://hdl.handle.net/10220/18581
• Institution: Nanyang Technological University

Virulence factor secretion and assembly occurs at spatially restricted foci in some Gram-positive bacteria. Given the essentiality of the general secretion pathway in bacteria and the contribution of virulence factors to disease progression, the foci that coordinate these processes are attractive an...