1,2,4-triazolo[1,5-a][1,3,5]triazines (5-azapurines): synthesis and biological activity

1,2,4-triazolo[1,5-a][1,3,5]triazines (5-azapurines): synthesis and biological activity

10.3987/REV-06-607

Saved in:

Bibliographic Details
Main Authors:	Dolzhenko, A.V., Chui, W.-K.
Other Authors:	PHARMACY
Format:	Article
Published:	2014
Online Access:	http://scholarbank.nus.edu.sg/handle/10635/105549
Tags:	Add Tag No Tags, Be the first to tag this record!
Institution:	National University of Singapore

Similar Items

Synthesis of 5,7-diamino1,2,4 triazolo[1,2-a1,3,5 triazines via annulation of 1,3,5-triazine ring onto 3(5)-amino-1,2,4-triazoles
by: Dolzhenko, A.V., et al.
Published: (2014)

Practical synthesis of regioisomeric 5(7)-amino-6,7(4,5)-dihydro[1,2,4]triazolo[1,5-a][1,3,5]triazines
by: Dolzhenko, A.V., et al.
Published: (2014)

A convenient method for the synthesis of 7-amino-substituted 1,2,4-triazolo[1,5-a][1,3,5]triazin-5-amines
by: Dolzhenko, A.V., et al.
Published: (2014)

5,5-Dimethyl-2-phenyl-4,5-dihydro-1,2,4-triazolo[1,5-a][1,3,5] triazin-7-amine
by: Dolzhenko, A.V., et al.
Published: (2014)

2-Phenyl-7-(4-pyridylmethylamino)-1,2,4-triazolo[1,5-a][1,3,5]triazin-5(4H) -one
by: Dolzhenko, A.V., et al.
Published: (2014)

7-(4-Fluorobenzylamino)-2-phenyl-1,2,4-triazolo[1,5-a][1,3,5] triazin-5-amine methanol disolvate
by: Dolzhenko, A.V., et al.
Published: (2014)

Synthesis and biological activity of fluorinated 7-aryl-2-pyridyl-6,7-dihydro[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-amines [1]
by: Dolzhenko, A.V., et al.
Published: (2014)

7,7-Dimethyl-2-phenyl-6,7-dihydro-1,2,4-triazolo[1,5-a][1,3,5] triazin-5-amine
by: Dolzhenko, A.V., et al.
Published: (2014)

Synthesis and in vitro evaluation of 1,2,4-triazolo[1,5-a][1,3,5]triazine derivatives as thymidine phosphorylase inhibitors
by: Bera, H., et al.
Published: (2014)

Pyrazolo[1,5-α][1,3,5]triazines (5-Aza-9-deazapurines): Synthesis and biological activity
by: Dolzhenko, A.V., et al.
Published: (2014)

Synthesis and biological activity of fluorinated 7-benzylamino-2-phenyl-1,2,4-triazolo[1,5-a][1,3,5]triazin-5-amines
by: Dolzhenko Anna V., et al.
Published: (2016)

Synthesis, anti-thymidine phosphorylase activity and molecular docking of 5-thioxo-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-ones
by: Bera, H., et al.
Published: (2014)

Molecular and crystal structure of 7,7-dimethyl-2-pyridin-4-yl- 6,7-dihydro-1,2,4-triazolo[1,5-a][1,3,5]triazin-5-amine [1]
by: Dolzhenko A.V., et al.
Published: (2020)

7-Dimethyl-amino-2-phenyl-1,2,4-triazolo[1,5-a][1,3,5]triazin-5-amine methanol solvate
by: Dolzhenko, A.V., et al.
Published: (2014)

Advances in chemistry and biological activity of fluorinated 1,3,5-triazines
by: Dolzhenko, A.V., et al.
Published: (2014)

A new synthesis of 2,8-disubstituted pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines
by: Dolzhenko, A.V., et al.
Published: (2014)

A structure-activity relationship study of 1,2,4-triazolo[1,5-a][1,3,5] triazin-5,7-dione and its 5-thioxo analogues on anti-thymidine phosphorylase and associated anti-angiogenic activities
by: Bera, H., et al.
Published: (2014)

Synthesis and structure of 3,4-dihydropyrido[2',3':3,4]pyrazolo[1,5-a][1,3, 5]triazin-2-amines [1]
by: Dolzhenko, A.V., et al.
Published: (2014)

Synthesis and tautomerism study of 6-benzoylmethyl-1,3,5-triazin-2,4- diamine
by: Sachdeva, N., et al.
Published: (2014)

8-Methyl-2-[4-(trifluoromethyl)phenyl]-8H-pyrazolo-[4,3-e][1,2,4] triazolo[1,5-c]pyrimidin-5-amine methanol disolvate
by: Dolzhenko, A.V., et al.
Published: (2014)

Synthesis and biological activity of 1,3,5-triazino[1,2-a]benzimidazol-2- amines
by: Dolzhenko, A.V., et al.
Published: (2014)

4-Phenethylthio-2-phenylpyrazolo[1,5-a][1,3,5]triazin-7(6H)-one
by: Smolnikov, S.A, et al.
Published: (2020)

3-Phenyl-1H-1,2,4-triazol-5-amine-5-phenyl-1H-1,2,4-triazol-3-amine (1/1)
by: Dolzhenko, A.V., et al.
Published: (2014)

An aqueous medium synthesis and tautomerism study of 3(5)-amino-1,2,4-triazoles
by: Dolzhenko, A.V., et al.
Published: (2014)

Synthesis and biological activity of fluorinated 2-amino-4-aryl-3,4- dihydro[1,3,5]triazino[1,2-a]benzimidazoles
by: Dolzhenko, A.V., et al.
Published: (2014)

Synthesis of ethyl 6-aryl-4-oxo-4,6-dihydro-1(12)(13)H-pyrimido-[2′, 1′:4,5][1,3,5]triazino[1,2-a]benzimidazole-3-carboxylates
by: Dolzhenko, A.V., et al.
Published: (2014)

Synthesis of new heterocyclic system: 1(5)H-1,5-diazacycl[3.3.2]azine-2,4-dione
by: Dolzhenko, A.V., et al.
Published: (2014)

Fragment-based approach to the design of 5-chlorouracil-linked-pyrazolo[1, 5-a][1,3,5]triazines as thymidine phosphorylase inhibitors
by: Sun, L., et al.
Published: (2014)

Simple synthesis of 2-amino-4-(het)aryl-4,6-dihydro-1(3)(11)H-[1,3,5] triazino[2,1-b]quinazolin-6-ones [1]
by: Dolzhenko, A.V., et al.
Published: (2014)

Regioselective synthesis of pyrimido[1,2-a][1,3,5]triazin-6-ones via reaction of 1-(6-oxo-1,6-dihydropyrimidin-2-yl)guanidines with triethylorthoacetate: Observation of an unexpected rearrangement
by: Sachdeva, N., et al.
Published: (2014)

3-Pyridin-2-yl-1H-1,2,4-triazol-5-amine
by: Dolzhenko, A.V., et al.
Published: (2014)

4,4-Dimethyl-3,4-dihydropyrido-[2′,3′:3,4]pyrazolo[1,5-a][1,3, 5]triazin-2-amine ethanol monosolvate
by: Dolzhenko, A.V., et al.
Published: (2014)

N-Carbethoxy-N'-(3-phenyl-1H-1,2,4-triazol-5-yl)thiourea
by: Dolzhenko, A.V., et al.
Published: (2014)

Synthesis of pyrazolo[1,5-a][1,3,5]triazine derivatives as inhibitors of thymidine phosphorylase
by: Sun, L., et al.
Published: (2014)

Synthesis and pharmacological characterization of a new series of 5,7-disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazine derivatives as adenosine receptor antagonists: A preliminary inspection of ligand-receptor recognition process
by: Pastorin, G., et al.
Published: (2014)

N-Carbethoxy-N'-[3-(4-methylphenyl)-1H-1,2,4-triazol-5-yl]thiourea
by: Dolzhenko, A.V., et al.
Published: (2014)

4-Amino-2,8-dimethyl-6H-pyrimido[1,2-a][1,3,5]triazin-6-one
by: Sachdeva, N., et al.
Published: (2014)

Synthesis, in vitro evaluation of thymidine phosphorylase inhibitory activity, and in silico study of 1,3,5-triazin-2,4-dione and its fused analogues
by: Bera, H., et al.
Published: (2014)

A monoclinic polymorph of N-ethoxycarbonyl-N′-(3-phenyl-1H-1,2,4- triazol-5-yl)thiourea
by: Dolzhenko, A.V., et al.
Published: (2014)

2-Amino-4-(4-bromo-phen-yl)-8-trifluoro-methyl-3,4-dihydropyrimido[1,2-a] [1,3,5]triazin-6(5H)-one
by: Dolzhenko, A.V., et al.
Published: (2014)