Bioactivation and hepatotoxicity of nitroaromatic drugs

Bioactivation and hepatotoxicity of nitroaromatic drugs

10.2174/138920006778520606

Saved in:

Bibliographic Details
Main Authors:	Boelsterli, U.A., Ho, H.K., Zhou, S., Leow, K.Y.
Other Authors:	PHARMACY
Format:	Review
Published:	2014
Subjects:	Drug-induced liver injury Flutamide Hepatotoxicity Mitochondria Nimesulide Nitroarene Nitroreduction Tolcapone
Online Access:	http://scholarbank.nus.edu.sg/handle/10635/106616
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Underlying mitochondrial dysfunction triggers flutamide-induced oxidative liver injury in a mouse model of idiosyncratic drug toxicity
by: Kashimshetty, R., et al.
Published: (2014)

Mitochondrial abnormalities-A link to idiosyncratic drug hepatotoxicity?
by: Boelsterli, U.A., et al.
Published: (2011)

Hypothermia Advocates Functional Mitochondria and Alleviates Oxidative Stress to Combat Acetaminophen-Induced Hepatotoxicity
by: Tan, Y.L., et al.
Published: (2021)

Mitochondrial permeability transition as a source of superoxide anion induced by the nitroaromatic drug nimesulide in vitro
by: Tay, V.K.S., et al.
Published: (2011)

Troglitazone-induced hepatic necrosis in an animal model of silent genetic mitochondrial abnormalities
by: Ong, M.M.K., et al.
Published: (2011)

Integrative toxicoproteomics implicates impaired mitochondrial glutathione import as an off-target effect of troglitazone
by: Lee, Y.H., et al.
Published: (2014)

A double-blinded randomized controlled trial of silymarin for the prevention of antituberculosis drug-induced liver injury
by: Chote Luangchosiri, et al.
Published: (2017)

Moderate Hypothermia Effectively Alleviates Acetaminophen-Induced Liver Injury With Prolonged Action Beyond Cooling
by: Tan, Y.L., et al.
Published: (2021)

Porcine hepatocytes culture on biofunctionalized 3D inverted colloidal crystal scaffolds as an in vitro model for predicting drug hepatotoxicity
by: Wu, Lingyan, et al.
Published: (2019)

Expression dynamics of the hepatic mitochondrial proteome of the Sod2+/- mouse in response to troglitazone administration
by: LEE YIE HOU
Published: (2010)

Troglitazone-induced hepatic mitochondrial proteome expression dynamics in heterozygous Sod2+/- mice: Two-stage oxidative injury
by: Lee, Y.H., et al.
Published: (2014)

Troglitazone-induced hepatic mitochondrial proteome expression dynamics in heterozygous Sod2+/-mice: Two-stage oxidative injury
by: Lee, Y.H., et al.
Published: (2011)

Mixed learning algorithms and features ensemble in hepatotoxicity prediction
by: Liew, C.Y., et al.
Published: (2014)

Escitalopram-induced liver injury: A case report and review of literature
by: Ng, Q.X., et al.
Published: (2021)

Presentation of drug-induced liver injury in Singapore
by: Wai, C.-T.
Published: (2011)

Drug induced liver injury: East versus West - A systematic review and meta-analysis
by: Low, E.X.S., et al.
Published: (2021)

The SOD2 mutant mouse as a model for oxidative stress: A functional proteomics perspective
by: Lee, Y.H., et al.
Published: (2011)

The SOD2 mutant mouse as a model for oxidative stress: A functional proteomics perspective
by: Lee, Y.H., et al.
Published: (2014)

Effect of CYP3A4 inducer dexamethasone on hepatotoxicity of lapatinib: Clinical and in vitro evidence
by: Teo, Y.L., et al.
Published: (2014)

Critical role of free cytosolic calcium, but not uncoupling, in mitochondrial permeability transition and cell death induced by diclofenac oxidative metabolites in immortalized human hepatocytes
by: Lim, M.S., et al.
Published: (2011)

Development of a scalable throughput Drug hepatotoxicity testing platform based on microfabricated galactosylated silicon nitride membranes
by: ZHANG SHUFANG
Published: (2010)

Investigation of the role of the thiazolidinedione ring of troglitazone in inducing hepatotoxicity
by: Saha, S., et al.
Published: (2014)

Acetaminophen psi parameter: a useful tool to quantify hepatotoxicity risk in acute acetaminophen overdose
by: Summon Chomchai, et al.
Published: (2015)

An evaluation of the in vitro roles and mechanisms of silibinin in reducing pyrazinamide-and isoniazid-induced hepatocellular damage
by: Goh, Z.-H., et al.
Published: (2021)

The Mechanistic Role of Mitochondrial Oxidative stress in Troglitazone - Induced Apoptosis in Human Hepatocytes
by: LIM LAY KENG
Published: (2010)

Hepatotoxicity of thiazolidinedione antidiabetic drugs: a structural toxicity relationship study
by: SUDIPTA SAHA
Published: (2011)

Exploring Mesenchymal Stem Cell-Derived Exosome and Tocotrienol (T3) as Therapeutic Agents in Drug-Induced Liver Injury (DILI)
by: TAN CHEAU YIH
Published: (2015)

Role of oxidative stress and mitochondrial changes in cyanobacteria-induced apoptosis and hepatotoxicity
by: Ding, W.-X., et al.
Published: (2012)

DETECTION OF DRUG-INDUCED LIVER INJURY IN ELECTRONIC MEDICAL RECORDS
by: TAN ENG HOOI
Published: (2020)

Oxidative bioactivation and toxicity of leflunomide in immortalized human hepatocytes and kinetics of the non-enzymatic conversion to its major metabolite, A77 1726
by: Seah, Q.M., et al.
Published: (2014)

Reversible time-dependent inhibition of cytochrome P450 enzymes by duloxetine and inertness of its thiophene ring towards bioactivation
by: Chan, C.Y., et al.
Published: (2014)

Efficacy of dose modification of gefitinib after hepatotoxicity in late-line treatment of EGFR mutated advanced non-small cell lung cancer: A case report
by: Chaichana Chantharakhit
Published: (2019)

Risk of tyrosine kinase inhibitors-induced hepatotoxicity in cancer patients: A meta-analysis
by: Teo, Y.L., et al.
Published: (2014)

Leflunomide or A77 1726 protect from acetaminophen-induced cell injury through inhibition of JNK-mediated mitochondrial permeability transition in immortalized human hepatocytes
by: Latchoumycandane, C., et al.
Published: (2011)

EVALUATION OF ANTI-PROLIFERATIVE ACTIVITY AND HEPATOTOXICITY OF BOTANICALS AND BOTANICAL HEALTH PRODUCTS
by: PATEL DHAVALKUMAR NARENDRABHAI
Published: (2013)

Reduced mitochondrial coenzyme Q10 levels in HepG2 cells treated with high-dose simvastatin: A possible role in statin-induced hepatotoxicity?
by: Tavintharan, S., et al.
Published: (2011)

Reduced mitochondrial coenzyme Q10 levels in HepG2 cells treated with high-dose simvastatin: A possible role in statin-induced hepatotoxicity?
by: Tavintharan, S., et al.
Published: (2011)

Determination of Barakol and Anthraquinone contents and hepatotoxicity evaluation of Sanna Siamea extracts
by: Tanit Padumanonda
Published: (2023)

Image-based tissue informatics - TAA induced hepatotoxicity model
by: SHAO LIN
Published: (2010)

A robust high-throughput sandwich cell-based drug screening platform
by: Zhang, S., et al.
Published: (2014)