Structure-activity studies of Mdm2/Mdm4-binding stapled peptides comprising non-natural amino acids

10.1371/journal.pone.0189379

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Main Authors:	Chee S.M.Q., Wongsantichon J., Siau J., Thean D., Ferrer F., Robinson R.C., Lane D.P., Brown C.J., Ghadessy F.J.
Other Authors:	BIOCHEMISTRY
Format:	Article
Published:	2019
Subjects:	6 chlorotryptophan protein MDM2 protein MDMX protein p53 tryptophan unclassified drug amino acid MDM2 protein, human MDM4 protein, human nuclear protein oncoprotein peptide protein binding Article binding affinity controlled study enzyme activation Escherichia coli limit of quantitation nonhuman protein expression protein function protein modification protein purification amino acid sequence chemistry human metabolism sequence alignment structure activity relation X ray crystallography Amino Acid Sequence Amino Acids Crystallography, X-Ray Humans Nuclear Proteins Peptides Protein Binding Proto-Oncogene Proteins Proto-Oncogene Proteins c-mdm2 Sequence Alignment Structure-Activity Relationship
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/161243
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1612432024-04-22T02:51:27Z Structure-activity studies of Mdm2/Mdm4-binding stapled peptides comprising non-natural amino acids Chee S.M.Q. Wongsantichon J. Siau J. Thean D. Ferrer F. Robinson R.C. Lane D.P. Brown C.J. Ghadessy F.J. BIOCHEMISTRY CHEMICAL & BIOMOLECULAR ENGINEERING 6 chlorotryptophan protein MDM2 protein MDMX protein p53 tryptophan unclassified drug amino acid MDM2 protein, human MDM4 protein, human nuclear protein oncoprotein peptide protein binding protein MDM2 Article binding affinity controlled study enzyme activation Escherichia coli limit of quantitation nonhuman protein binding protein expression protein function protein modification protein purification amino acid sequence chemistry human metabolism sequence alignment structure activity relation X ray crystallography Amino Acid Sequence Amino Acids Crystallography, X-Ray Humans Nuclear Proteins Peptides Protein Binding Proto-Oncogene Proteins Proto-Oncogene Proteins c-mdm2 Sequence Alignment Structure-Activity Relationship 10.1371/journal.pone.0189379 PLoS ONE 12 12 e0189379 2019-11-01T08:18:29Z 2019-11-01T08:18:29Z 2017 Article Chee S.M.Q., Wongsantichon J., Siau J., Thean D., Ferrer F., Robinson R.C., Lane D.P., Brown C.J., Ghadessy F.J. (2017). Structure-activity studies of Mdm2/Mdm4-binding stapled peptides comprising non-natural amino acids. PLoS ONE 12 (12) : e0189379. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0189379 19326203 https://scholarbank.nus.edu.sg/handle/10635/161243 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20191101
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	6 chlorotryptophan protein MDM2 protein MDMX protein p53 tryptophan unclassified drug amino acid MDM2 protein, human MDM4 protein, human nuclear protein oncoprotein peptide protein binding protein MDM2 Article binding affinity controlled study enzyme activation Escherichia coli limit of quantitation nonhuman protein binding protein expression protein function protein modification protein purification amino acid sequence chemistry human metabolism sequence alignment structure activity relation X ray crystallography Amino Acid Sequence Amino Acids Crystallography, X-Ray Humans Nuclear Proteins Peptides Protein Binding Proto-Oncogene Proteins Proto-Oncogene Proteins c-mdm2 Sequence Alignment Structure-Activity Relationship
spellingShingle	6 chlorotryptophan protein MDM2 protein MDMX protein p53 tryptophan unclassified drug amino acid MDM2 protein, human MDM4 protein, human nuclear protein oncoprotein peptide protein binding protein MDM2 Article binding affinity controlled study enzyme activation Escherichia coli limit of quantitation nonhuman protein binding protein expression protein function protein modification protein purification amino acid sequence chemistry human metabolism sequence alignment structure activity relation X ray crystallography Amino Acid Sequence Amino Acids Crystallography, X-Ray Humans Nuclear Proteins Peptides Protein Binding Proto-Oncogene Proteins Proto-Oncogene Proteins c-mdm2 Sequence Alignment Structure-Activity Relationship Chee S.M.Q. Wongsantichon J. Siau J. Thean D. Ferrer F. Robinson R.C. Lane D.P. Brown C.J. Ghadessy F.J. Structure-activity studies of Mdm2/Mdm4-binding stapled peptides comprising non-natural amino acids
description	10.1371/journal.pone.0189379
author2	BIOCHEMISTRY
author_facet	BIOCHEMISTRY Chee S.M.Q. Wongsantichon J. Siau J. Thean D. Ferrer F. Robinson R.C. Lane D.P. Brown C.J. Ghadessy F.J.
format	Article
author	Chee S.M.Q. Wongsantichon J. Siau J. Thean D. Ferrer F. Robinson R.C. Lane D.P. Brown C.J. Ghadessy F.J.
author_sort	Chee S.M.Q.
title	Structure-activity studies of Mdm2/Mdm4-binding stapled peptides comprising non-natural amino acids
title_short	Structure-activity studies of Mdm2/Mdm4-binding stapled peptides comprising non-natural amino acids
title_full	Structure-activity studies of Mdm2/Mdm4-binding stapled peptides comprising non-natural amino acids
title_fullStr	Structure-activity studies of Mdm2/Mdm4-binding stapled peptides comprising non-natural amino acids
title_full_unstemmed	Structure-activity studies of Mdm2/Mdm4-binding stapled peptides comprising non-natural amino acids
title_sort	structure-activity studies of mdm2/mdm4-binding stapled peptides comprising non-natural amino acids
publishDate	2019
url	https://scholarbank.nus.edu.sg/handle/10635/161243
_version_	1800913785389580288

Structure-activity studies of Mdm2/Mdm4-binding stapled peptides comprising non-natural amino acids

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